Starting dose of Pozemet should be based on the patient’s current treatment of pioglitazone and/or metformin. Pozemet should be given with meals in divided daily doses to reduce the gastrointestinal side effects associated with metformin.
For patients inadequately controlled on metformin monotherapy
Pozemet may be initiated at either 15 mg/500 mg or 15 mg/850 mg tablet strength based on usual starting dose of pioglitazone (15-30 mg daily), once or twice daily and gradually titrated after assessing adequacy of therapeutic response.
For patients who initially responded to pioglitazone monotherapy & require additional glycemic control
Pozemet may be initiated at either 15 mg/500 mg twice daily or 15 mg/850 mg tablet strength once daily based on the usual starting doses of metformin (500 mg twice daily or 850 mg daily) and gradually titrated after assessing adequacy of therapeutic response.
For patients switching from combination therapy of pioglitazone plus metformin as separate tablets
Pozemet may be initiated with either 15 mg/500 mg or 15 mg/850 mg tablet strengths based on the dose of pioglitazone and metformin already being taken.
Maximum Recommended Dose
The maximum recommended dose for pioglitazone is 45 mg & metformin is 2,550 mg daily in adults.