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PRODUCT

Afoxin

Generic:

Clarithromycin

Therapeutic Class:

Antibiotics

Composition:

Each Afoxin tablet contains 250 mg or 500 mg of clarithromycin.

Description:

Afoxin (clarithromycin) is a semi-synthetic macrolide antibiotic.

Indications:

Afoxin tablets are indicated for the treatment of mild to moderate infections caused by susceptible strains of the designated microorganisms in the conditions as listed below:

Adults & Children:

- Pharyngitis/tonsillitis
- Acute maxillary sinusitis
- Acute bacterial exacerbation of chronic bronchitis (for adults)
- Community-Acquired Pneumonia
- Uncomplicated skin and skin structure infections
- Afoxin (clarithromycin) tablets in combination with amoxicillin and lansoprazole or
omeprazole, as triple therapy, are indicated for the treatment of patients with H. pylori
infection and duodenal ulcer disease to eradicate H. pylori (for adults) .
- Afoxin tablets in combination with omeprazole capsules or ranitidine bismuth citrate
tablets are also indicated for the treatment of patients with an active duodenal ulcer
associated with H. pylori infection (for adults).

Dosage:

Afoxin (clarithromycin) tablets may be given with or without food.

Adult :

For pharyngitis/tonsillitis: 250 mg (q12h) for 10 days
For acute maxillary sinusitis: 500 mg (q12h) for 14 days
For acute exacerbation of chronic bronchitis: 250 mg - 500 mg (q12h) for 7-14 days
For community-acquired pneumonia: 250 mg (q12h) for 7-14 days
For uncomplicated skin & skin structure infections: 250 mg (q12h) for 7-14 days

H. pylori eradication to reduce the risk of duodenal ulcer recurrence

Triple therapy: Afoxin/lansoprazole/amoxicillin

The recommended adult dose is 500 mg Afoxin, 30 mg lansoprazole, and 1 gram amoxicillin, all given twice daily (q12h) for 10 or 14 days.

Triple therapy: Afoxin/omeprazole/amoxicillin

The recommended adult dose is 500 mg Afoxin, 20 mg omeprazole, and 1 gram amoxicillin, all given twice daily (q12h) for 10 days.

Dual therapy: Afoxin/omeprazole

The recommended adult dose is 500 mg Afoxin given three times daily (q8h) and 40 mg omeprazole given once daily (qAM) for 14 days.

Dual therapy: Afoxin/ranitidine bismuth citrate

The recommended adult dose is 500 mg Afoxin given twice daily (q12h) or three times daily (q8h) and 400 mg ranitidine bismuth citrate given twice daily (q12h) for 14 days.

Children:

The usual recommended daily dosage is 15 mg/kg/day divided q12h for 10 days.

PEDIATRIC DOSAGE GUIDELINES

Based on body weight dosing calculated on 7.5 mg/kg
Weight		Dose(q12h)
Kg	lbs	Dose(q12h)
17	37	125 mg
25	55	187.5 mg
33	73	250 mg

Presentations:

Afoxin 250 mg tablet is available in the pack of 10’s.
Afoxin 500 mg tablet is available in the pack of 10’s.